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Skip to main content AACR Publications Blood Cancer Discovery Cancer Discovery Cancer Epidemiology, Biomarkers & Prevention Cancer Immunology Research Cancer Prevention Research Cancer Research Clinical Cancer Research Molecular Cancer Research Molecular Cancer Therapeutics Register Log in My Cart Advertisement Main menu Home About The Journal AACR Journals Journal Sections Subscriptions Reviewing Permissions and Reprints Articles OnlineFirst Current Issue Past Issues Collections COVID-19 & Cancer Resource Center Clinical Trials Immuno-oncology Editors' Picks "Best of" Collection For Authors Information for Authors Author Services Best of: Author Profiles Submit Alerts Table of Contents Editors' Picks OnlineFirst Citation Author/Keyword My Alert Summary & Preferences News Cancer Discovery News Journal Press Releases COVID-19 Search More Search for this keyword Advanced Search AACR Publications Blood Cancer Discovery Cancer Discovery Cancer Epidemiology, Biomarkers & Prevention Cancer Immunology Research Cancer Prevention Research Cancer Research Clinical Cancer Research Molecular Cancer Research Molecular Cancer Therapeutics User menu Register Log in My Cart Search Search for this keyword Advanced search Home About The Journal AACR Journals Journal Sections Subscriptions Reviewing Permissions and Reprints Articles OnlineFirst Current Issue Past Issues Collections COVID-19 & Cancer Resource Center Clinical Trials Immuno-oncology Editors' Picks "Best of" Collection For Authors Information for Authors Author Services Best of: Author Profiles Submit Alerts Table of Contents Editors' Picks OnlineFirst Citation Author/Keyword My Alert Summary & Preferences News Cancer Discovery News Journal Press Releases COVID-19 Search More Search for this keyword Advanced Search The AACR remains fully committed to supporting publishing operations throughout this challenging time, while still remaining flexible and supportive of the author, reviewer, and editor communities that we serve. If you have any questions or concerns, please reach out to a member of the AACR publishing staff. Please visit the COVID-19 & Cancer Resource Center where COVID-related content is freely available . Read, Science in Society: Priority COVID-19 vaccination for patients with cancer while vaccine supply is limited Read the December issue! About the cover: Binkley et al., found that loss-of-function mutations in KEAP1 or gain-of-function mutations in NFE2L2 were associated with increased risk of local recurrence after treatment. Find out more in the article. Cancer Discovery News website Keep up with findings in the cancer research field via our website, highlighting must-read industry news, and on Twitter @CD_AACR! Read, Poor Survival and Differential Impact of Genetic Features of Black Patients with Acute Myeloid Leukemia, Bhavana Bhatnagar, et al. Research Brief Read: Lower airway dysbiosis affects lung cancer progression, Jun-Chieh J Tsay, et al. Research Article Read: Selection of oncogenic mutant clones in normal human skin varies with body site, Joanna C Fowler, et al. 1 2 3 4 5 From the Current Issue Research Articles The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies Angela Su , Frank Ling , Camille Vaganay , Gaetano Sodaro , Chaïma Benaksas , Reinaldo Dal Bello , Antoine Forget , Bryann Pardieu , Kevin H. Lin , Justine C. Rutter , Christopher F. Bassil , Gael Fortin , Justine Pasanisi , Iléana Antony-Debré , Gabriela Alexe , Jean-François Benoist , Alain Pruvost , Yana Pikman , Jun Qi , Marie-Hélène Schlageter , Jean-Baptiste Micol , Giovanni Roti , Thomas Cluzeau , Hervé Dombret , Claude Preudhomme , Nina Fenouille , Lina Benajiba , Hava M. Golan , Kimberly Stegmaier , Camille Lobry , Kris C. Wood , Raphael Itzykson and Alexandre Puissant Cancer Discov December 1 2020 10 (12) 1894-1911; DOI:10.1158/2159-8290.CD-19-0970 In vitro and in vivo experiments using models of acute myeloid leukemia showed that the folate cycle enzyme MTHFR mediated response to BET inhibitors, which target oncogenic MYC expression and are in phase I and II clinical trials. Research Articles Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers Xinxin Song , Zhuan Zhou , Hongchun Li , Yifan Xue , Xinghua Lu , Ivet Bahar , Oliver Kepp , Mien-Chie Hung , Guido Kroemer and Yong Wan Cancer Discov December 1 2020 10 (12) 1872-1893; DOI:10.1158/2159-8290.CD-20-0402 Preventing glycosylation of the immuno-suppressive transmembrane protein B7-H4 increased its ubiquitination and subsequent degradation, and inhibition of B7-H4 glycosylation in vivo improved immunogenicity of immune-cold tumors. Research Articles Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML Sheng Li , Xiaowen Chen , Jiahui Wang , Cem Meydan , Jacob L. Glass , Alan H. Shih , Ruud Delwel , Ross L. Levine , Christopher E. Mason and Ari M. Melnick Cancer Discov December 1 2020 10 (12) 1934-1949; DOI:10.1158/2159-8290.CD-19-0897 Mutations that drive acute myeloid leukemia, especially in combination, induced epigenetic alterations prior to leukemogenesis, resulting in epigenetic diversity that was associated with poor prognosis in patients. Recent Reviews Reviews Tumor Mutational Burden as a Predictive Biomarker in Solid Tumors Dan Sha , Zhaohui Jin , Jan Budczies , Klaus Kluck , Albrecht Stenzinger and Frank A. Sinicrope Cancer Discov December 1 2020 10 (12) 1808-1825; DOI:10.1158/2159-8290.CD-20-0522 Reviews Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy Sarah-Maria Fendt , Christian Frezza and Ayelet Erez Cancer Discov December 1 2020 10 (12) 1797-1807; DOI:10.1158/2159-8290.CD-20-0844 Mini review Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy Maria Jose Serrano , Maria Carmen Garrido-Navas , Juan Jose Diaz Mochon , Massimo Cristofanilli , Ignacio Gil-Bazo , Patrick Pauwels , Umberto Malapelle , Alessandro Russo , Jose A. Lorente , Antonio J. Ruiz-Rodriguez , Luis G. Paz-Ares , Eduardo Vilar , Luis E. Raez , Andres F. Cardona and Christian Rolfo ; on behalf of the International Society of Liquid Biopsy Cancer Discov November 1 2020 10 (11) 1635-1644; DOI:10.1158/2159-8290.CD-20-0466 Mini Review Cancer in the Fourth Dimension: What Is the Impact of Circadian Disruption? Marie Pariollaud and Katja A. Lamia Cancer Discov October 1 2020 10 (10) 1455-1464; DOI:10.1158/2159-8290.CD-20-0413 News from Cancer Discovery Free Article | As Pandemic Continues, Screening Concerns Grow Patients hesitant to return to health centers; missed exams mean more advanced disease. FDA Encourages Greater Trial Diversity Strategies include broadening eligibility criteria and reaching out to minority, low-income patients. Free Article | Cancer Immunotherapies Helped Shape COVID Vaccines Prior work in oncology underpins the record-breaking speed of development. More Cancer Discovery news » Noted This Week, December 11–17 » TITLE COPY TITLE COPY TITLE COPY END TEMPLATE -- OnlineFirst Research Articles & Briefs Triplet Therapy of Palbociclib, Taselisib, and Fulvestrant Javier Pascual , et al. Glioblastoma homeostasis revealed by synthetic genetic tracing Matthias Jürgen Schmitt , et al. Avapritinib Resistance in PDGFRA -Mutant GIST Susanne Grunewald , et al. Tumor-Selective Anti-CD137 Antibody Activated by exATP Mika Kamata-Sakurai , et al. Nuclear Pore Assembly Is a Vulnerability of Cancer Cells Stephen Sakuma , et al. Show more Advertisement OnlineFirst Research Watch Obesity Promotes Metabolic Rewiring That Starves Cytotoxic T Cells Gut Microbiome Manipulation May Facilitate Immunotherapy Response Method Aids Determination of Metastatic Potential of Cancer Cell Lines Response to Adoptive Cell Therapy Is Predicted by Stem-Like T Cells Frameshifts in Microsatellite-Unstable Tumors Create Shared Neoantigens Show more Trending - Altmetric Priority COV...